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DeCS
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Descriptor English:
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Neuritis, Autoimmune, Experimental
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Descriptor Spanish:
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Neuritis Autoinmune Experimental
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Descriptor Portuguese:
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Neurite Auto-Imune Experimental
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Synonyms English:
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Autoimmune Neuritis, Experimental
Allergic Neuritis, Experimental
Neuritis, Experimental Allergic
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Tree Number:
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C10.114.703.700
C10.668.829.650.500
C20.111.258.625.700
E05.598.500.500.875
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Definition English:
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An experimental animal model for the demyelinating disease of GUILLAINE-BARRE SYNDROME. In the most frequently used protocol, animals are injected with a peripheral nerve tissue protein homogenate. After approximately 2 weeks the animals develop a neuropathy secondary to a T cell-mediated autoimmune response directed towards the MYELIN P2 PROTEIN in peripheral nerves. Pathologic findings include a perivascular accumulation of macrophages and T lymphocytes in the peripheral nervous system, similar to that seen in the Guillaine-Barre syndrome. (From Adams et al., Principles of Neurology, 6th ed, p1314; J Neuroimmunol 1998 Apr 1;84(1):40-52) |
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Indexing Annotation English:
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coordinate with GUILLAINE-BARRE SYNDROME if pertinent; DF: NEURITIS EXPER ALLERGIC
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History Note English:
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2005 (1982)
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Allowable Qualifiers English:
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Record Number:
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9637
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Unique Identifier:
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D009444
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Occurrence in VHL:
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Similar:
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DeCS CID-10 SciELO LILACS LIS
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